Sarah Ford | November 20, 2014
Drug Restores Memory Function in Alzheimer’s Model
Building on earlier work funded by BrightFocus, researchers have discovered a promising new drug compound that reverses some
Alzheimer’s effects on memory in mice.
Four years ago, a research team led by BrightFocus grantee and Nobel Laureate Dr. Paul Greengard established the connection between increased striatal-enriched tyrosine phosphatase (STEP) levels and Alzheimer’s changes in mice, and showed that removing STEP had the effect of restoring synaptic connections.
Since their discovery of STEP, this research team has been searching for a drug that would block its damaging effects on brain synapses. They focused their efforts on finding a STEP inhibitor, studying thousands of small molecules in their quest.
Get Resources and Insights Straight To Your Inbox
Explore More Articles
Celebrating Juneteenth and Continuing to Work in Solidarity for Racial Justice, Equality, and Equity
June 19 — also known as Juneteenth, or the nation’s second Independence Day — commemorates the end of slavery in Texas, and therefore the nation,…
Read Article
LGBTQIA+ Pride Month 2024
In honor of the 1969 Stonewall Uprising in Manhattan – considered the tipping point for the Gay Liberation Movement in the United States – each…
Read Article
Men’s Health Month
June is Men’s Health Month, a time to focus on the unique health challenges faced by men and to encourage them to prioritize their physical…
Read ArticleGet Resources and Insights Straight To Your Inbox
Receive our monthly/bi-monthly newsletter filled with information about causes, nonprofit impact, and topics important for corporate social responsibility and employee engagement professionals, including disaster response, workplace giving, matching gifts, employee assistance funds, volunteering, scholarship award program management, grantmaking, and other philanthropic initiatives.
